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Dozens of men crammed into a small, dark, window-less prison cell, peering out from the barred doorway, pleading looks on their sweaty faces; this is the image I cannot forget from a week-long research trip to Haiti in 2016. Many prisons around the world are essentially factories for production of TB, including drug-resistant TB, now the single biggest infectious disease killer in the world. Unless the world tackles prison conditions, ending this disease will remain just a distant dream.